The long-term studies in animals have not beenconducted to evaluate order soma cheapest Peoria the carcinogenic potential of carisoprodol.
In published studies, carisoprodol was mutagenic in order soma cheapest Peoria the in vitro test of lymphoma in order soma cheapest Peoria mice leabsence of metabolizing enzymes, but was not order soma cheapest Peoria mutagenic in the presence of metabolizing enzymes.
Carisoprodol was clastogenic in the chromosomal aberration test in vitro with cells of Chinese hamster ovary, with or without the presence of metabolizing enzymes. Other genotoxicity Depruebas led to negative results. Carisoprodol was not mutagenic in reverse mutation assay of Ames strains of S. typhimurium, with or without metabolizing enzymes, and was not clastogenic in a cell in vivo mouse micronucleus circulating blood. SOMA was not formally evaluated the effects on fertility. Published reproductive studies of carisoprodol in mice found no alteration in fertility although an alteration in reproductive cycles characterized by a greater time spent in estrus was observed with a dose of carisoprodol 1200 mg / kg / day . In a toxicology study of 13 order soma cheapest Peoria weeks do not determine the fertility of the mouse testis weight and sperm motility was reduced at a dose of 1200 mg / order soma cheapest Peoria kg / day.
In both studies, the NOEL was 750 mg / kg / day, corresponding to approximately 2.6 times the equivalent human dose of 350 mg four times daily, based on a comparison of the body surface. The importance of these findings for human fertility is unknown. Animal studies indicate that carisoprodol crosses the placenta and causes adverse effects on fetal growth and postnatal survival. The major metabolite of carisoprodol, meprobamate, is an approved anxiolytic. Retrospective, post-marketing studies do not show a consistent order soma cheapest Peoria association between maternal consumption order soma cheapest Peoria of meprobamate and an order soma cheapest Peoria increased risk of birth defects in particular. Animal studies have not adequately evaluated the teratogenic effects of carisoprodol.
There order soma cheapest Peoria was no increased incidence of congenital malformations noted in reproductive studies in rats, rabbits and mice treated with meprobamate. Retrospective, post-marketing studies of meprobamate during human pregnancy are order soma cheapest Peoria equivocal for demonstrating an increased risk of birth defects following exposure during the first quarter. Among the studies that have shown an increased risk of malformations incompatible types. In animal studies, carisoprodol reduced fetal weights, weight gain after birth, and postnatal survival at maternal doses equivalent to 1 to 1.5 times the human dose (based on a comparison of body surface).
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